Overview
Not intended for use as a standalone HRQL measure, the FACT-8D is a preference-based multi-attribute utility instrument (MAUI) developed by the University of Sydney which converts FACT-G scores to utilities. The 27 items from the FACT-G have been reduced to a smaller number for preference-based valuation techniques, resulting in 8 dimensions: nausea, pain, fatigue, sleep, work, worry about worsening health, sadness, and support from family and friends. The 9 FACT-G items that are included in the FACT-8D represent 8 dimensions, some of which are common to generic MAUIs such as pain and emotion. Importantly, they also include fatigue and nausea and other issues known to affect the health-related quality of life of cancer patients. In total, this descriptive system includes 32,768 possible health states, capturing a wide combination of common impacts of cancer on quality of life. The FACT-8D may therefore be more sensitive in cost-utility analysis of cancer therapies than generic MAUIs.
MEASURE NAME:
FACT-8D
VERSION:
1
NUMBER OF ITEMS:
9
PATIENT POPULATION:
Cancer patients 18 years and older
RECALL PERIOD:
Not applicable
RESPONSE SCALE:
Not applicable
DATA COLLECTION:
Not applicable
ADMINISTRATION:
Not applicable
SUBSCALE DOMAINS:
Nausea, Pain, Fatigue, Sleep, Work, Worry about worsening health, Sadness, Support from family and friends
TIME FOR COMPLETION:
Not applicable
SCORING:
Utility algorithm and scoring instructions with STATA and SPSS syntax using standard QALY model restrictions (King et al 2021). The scoring algorithm, derived using a preference based approach, provides a value set covering each health state described on a scale anchored on 0 (dead) and 1 (full health), suitable for estimating QALYs.
RELATED MEASURES:
Language Availability
Utilities can be scored from any available FACT-G language version using the FACT-8D scoring algorithm. Country-specific value sets are only currently available or under development for four English-speaking countries (Australia, Canada, US, UK) and Japanese (Japan). Country-specific value sets would need to be developed for any additional countries.
Please contact us for more information.
Licensing
Because the FACT-8D is a preference-based measure for economic evaluation rather than a standalone outcome measure like other FACIT measures, specific approval should be obtained from FACIT.org before developing value sets for any new countries. Please contact us for more details.
To license an available version of this measure for commercial or non-commercial use, please complete our registration form. All of the information provided in the form will be kept strictly confidential. For questions, please contact us.
Selected References
King MT, Norman R, Mercieca-Bebber R, Costa DSJ, McTaggart-Cowan H, Peacock S, Janda M, Müller F, Viney R, Pickard AS, Cella D; Multi-Attribute Utility in Cancer Consortium. The Functional Assessment of Cancer Therapy Eight Dimension (FACT-8D), a Multi-Attribute Utility Instrument Derived From the Cancer-Specific FACT-General (FACT-G) Quality of Life Questionnaire: Development and Australian Value Set. Value Health. 2021 Jun;24(6):862-873. doi: 10.1016/j.jval.2021.01.007. Epub 2021 May 7. PMID: 34119085.
Herdman M, Kerr C, Pavesi M, Garside J, Lloyd A, Cubi-Molla P, Devlin N. Testing the validity and responsiveness of a new cancer-specific health utility measure (FACT-8D) in relapsed/refractory mantle cell lymphoma, and comparison to EQ-5D-5L. J Patient Rep Outcomes. 2020 Mar 27;4(1):22. doi: 10.1186/s41687-020-0185-3. PMID: 32219576; PMCID: PMC7099111.
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